Aminopeptidases in Cardiovascular and Renal Function. Role as Predictive Renal Injury Biomarkers

Vargas, Félix; Wangesteen, Rosemary; Rodríguez-Gómez, Isabel; García-Estañ, Joaquín

Publication:
Aminopeptidases in Cardiovascular and Renal Function. Role as Predictive Renal Injury Biomarkers

dc.contributor.author	Vargas, Félix
dc.contributor.author	Wangesteen, Rosemary
dc.contributor.author	Rodríguez-Gómez, Isabel
dc.contributor.author	García-Estañ, Joaquín
dc.contributor.department	Fisiología
dc.date.accessioned	2024-01-23T12:34:17Z
dc.date.available	2024-01-23T12:34:17Z
dc.date.issued	2020-08-05
dc.description	© 2023. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in International Journal of Molecular Sciences	es
dc.description.abstract	Aminopeptidases (APs) are metalloenzymes that hydrolyze peptides and polypeptides by scission of the N-terminus amino acid and that also participate in the intracellular final digestion of proteins. APs play an important role in protein maturation, signal transduction, and cell-cycle control, among other processes. These enzymes are especially relevant in the control of cardiovascular and renal functions. APs participate in the regulation of the systemic and local renin–angiotensin system and also modulate the activity of neuropeptides, kinins, immunomodulatory peptides, and cytokines, even contributing to cholesterol uptake and angiogenesis. This review focuses on the role of four key APs, aspartyl-, alanyl-, glutamyl-, and leucyl-cystinyl-aminopeptidases, in the control of blood pressure (BP) and renal function and on their association with different cardiovascular and renal diseases. In this context, the effects of AP inhibitors are analyzed as therapeutic tools for BP control and renal diseases. Their role as urinary biomarkers of renal injury is also explored. The enzymatic activities of urinary APs, which act as hydrolyzing peptides on the luminal surface of the renal tubule, have emerged as early predictive renal injury biomarkers in both acute and chronic renal nephropathies, including those induced by nephrotoxic agents, obesity, hypertension, or diabetes. Hence, the analysis of urinary AP appears to be a promising diagnostic and prognostic approach to renal disease in both research and clinical settings.	es
dc.format	application/pdf	es
dc.format.extent	20	es
dc.identifier.citation	International Journal of Molecular Sciences 2020, 21, 5615;
dc.identifier.doi	https://doi.org/10.3390/ijms21165615
dc.identifier.issn	Print: 1661-6596
dc.identifier.issn	Electronic: 1422-0067
dc.identifier.uri	http://hdl.handle.net/10201/137595
dc.language	eng	es
dc.publisher	MDPI	es
dc.relation	Sin financiación externa a la Universidad	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Aminopeptidasas	es
dc.subject	Función Renal	es
dc.subject	Urinary aminopeptidases	es
dc.subject	Aiomarkers	es
dc.subject	Arterial hypertension	es
dc.subject	Renal function	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::612 - Fisiología	es
dc.title	Aminopeptidases in Cardiovascular and Renal Function. Role as Predictive Renal Injury Biomarkers	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es