Membrane peroxidation index and maximum lifespan are negatively correlated in fish of the genus Nothobranchius

Costa, J. de; Barja, G.; Almaida Pagán, Pedro Francisco

Publication:
Membrane peroxidation index and maximum lifespan are negatively correlated in fish of the genus Nothobranchius

dc.contributor.author	Costa, J. de
dc.contributor.author	Barja, G.
dc.contributor.author	Almaida Pagán, Pedro Francisco
dc.contributor.department	Fisiología
dc.contributor.department	Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), 28029 Madrid, Spain
dc.contributor.department	Department of Genetics, Physiology and Microbiology, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain.
dc.date.accessioned	2024-06-17T07:21:19Z
dc.date.available	2024-06-17T07:21:19Z
dc.date.issued	2020-04-22
dc.description	©2020 The Company of Biologists Ltd. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published, version of a Published Work that appeared in final form in Journal of Experimental Biology (JEB). To access the final edited and published work see https://doi.org/10.1242/jeb.224063
dc.description.abstract	The lipid composition of cell membranes is linked tometabolic rate and lifespan in mammals and birds but very little information is available for fish. In this study, three fish species of the short-lived annual genus Nothobranchius with different maximum lifespan potential (MLSP) and the longer-lived outgroup species Aphyosemion australe were studied to test whether they conform to the predictions of the longevity–homeoviscous adaptation (LHA) theory of ageing. Lipid analyses were performed in whole-fish samples and the peroxidation index (PIn) for every phospholipid (PL) class and for the whole membrane was calculated. Total PL content was significantly lower in A. australe and N. korthausae, the two species with the highest MLSP, and a negative correlation between membrane total PIn and fish MLSP was found, meaning that the longer-lived fish species have more saturated membranes and, therefore, a lower susceptibility to oxidative damage, as the LHA theory posits.	es
dc.format	application/pdf	es
dc.format.extent	5	es
dc.identifier.citation	Journal of Experimental Biology 223, jeb224063
dc.identifier.doi	10.1242/jeb.224063
dc.identifier.doi	https://doi.org/10.1242/jeb.224063
dc.identifier.issn	Print: 0022-0949
dc.identifier.issn	Electronic: 1477-9145
dc.identifier.uri	http://hdl.handle.net/10201/142366
dc.language	eng	es
dc.publisher	The Company of Biologists	es
dc.relation	This work was supported by Fundación ONCE (research grant to P.F.A.-P as part of the ‘Oportunidad al Talento’ programme for disabled scientists, co-financed by the European Social Fund), the Spanish Ministerio de Economia y Competitividad, the Instituto de Salud Carlos III through CIBERFES (CB16/10/00239), the Séneca Foundation through grant 19899/GERM/15 and the Spanish Ministerio de Ciencia, Innovacion y Universidades (RTI2018-093528-B-I00), all of them co-financed by FEDER.	es
dc.relation.publisherversion	https://journals.biologists.com/jeb/article/223/11/jeb224063/223591/Membrane-peroxidation-index-and-maximum-lifespan
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights	Atribución-CompartirIgual 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-sa/4.0/	*
dc.subject	Ageing	es
dc.subject	Annual fish
dc.subject	Longevity–homeoviscous theory
dc.subject	Lipids
dc.subject	Phospholipids
dc.title	Membrane peroxidation index and maximum lifespan are negatively correlated in fish of the genus Nothobranchius	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es