Publication: Abnormal periodic acidSchiff (PAS)-positive substance in the islets of Langerhans, pituitaries and adrenal glands of 139H scrapie-infected hamsters
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Date
1999
Authors
Ye, X. ; Scallet, A. ; Carp, R.I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Previous studies showed that the 139H strain
of scrapie injected intra-cerebrally in hamsters caused
obesity, and extensive histopathological changes in islets
of Langerhans and pituitaries. In the current study, we
report that an abnormal granular substance, which
stained positively with periodic acid-Schiff (PASpositive
substance; PPS), was found in the islets of
Langerhans, pituitaries, adrenal glands, in the lumens of
blood vessel cores (BVCs) and in blood vessels in 139Hinfected
hamsters, but not in either 263K-infected or
control hamsters. This substance was found in the
endocrine organs, forming grape-like or plaque-like
structures, which were small, round to ovoid, and
homogenous measuring up to 7pm in diameter and
usually grouped in clusters. PPS was not found in the
brains of control or scrapie-infected hamsters. Using
immunostaining for amyloid protein (PrP, 13A4), as well
as Congo red and thioflavin-S stains, no evidence was
found of amyloid plaque formation in the islets of
Langerhans, the adrenal glands, or the pituitaries of
139H- or 263K-infected hamsters. PPS might relate to
the pathological changes in the endocrine organs in
139H-infected hamsters.
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