Publication: Prolonged immobilization-induced stress delays alveolar bone healing. A histometric study in rats
Authors
Bombonato Prado, K.F. ; Lamano Carvalho, T.L. ; Franci, J.A.A. ; Brentegani, L.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The purpose of the present study was to
investigate the effect of prolonged immobilizationinduced
stress on reparative bone formation, using the
rat alveolar healing as an experimental protocol. Stress
was attained by immobilization for 2 hours a day,
beginning three days before extraction of the upper right
incisors and continuing until sacrifice. The stress
condition was assayed on the basis of plasma
corticosterone concentration (measured by doubleantibody
radioimmunoassay), which increased by 2.5 to
4 times in rats submitted to immobilization. The volume
density of neoformed bone filling the alveolar socket
was quantified by a histometric differential pointcounting
method 7 to 21 days following tooth extraction.
Stress caused a significant delay in reparative bone
increment, somewhat related to impairment of coagulum
remission andlor organization.
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Citation
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