Publication: Endothelial progenitor cells in health and disease
Authors
Ribatti, Doménico ; Nico, Beatrice ; Crivellato, E. ; Vacca, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
There is currently great excitement and
expectation in the stem cell community following the
discovery that multipotent stem cells can be cultured
from human fetal tissue and retain their ability to give
rise to a variety of differentiated cell types found in all
three embryonic germ layers.
Although the earliest sites of hematopoietic cell and
endothelial cell differentiation in the yolk sac blood
islands were identified about 100 years ago, cells with
hemangioblast properties have not yet been identified in
vivo. Endothelial cells differentiate from angioblasts in
the embryo and from endothelial progenitor cells,
mesoangioblasts and multipotent adult progenitor cells
in the adult bone marrow. Circulating endothelial
progenitor cells (EPC) have been detected in the
circulation after vascular injury and during tumor
growth. The molecular and cellular mechanisms
underlying EPC recruitment and differentiation are not
yet understood, and remain as one of the central issues in
stem cell biology.
For many years, the prevailing dogma stated that the
vessels in the embryo develop from endothelial
progenitors, whereas sprouting of vessels in the adult results only from division of differentiated endothelial
cells. Recent evidence, however, indicates that EPC
contribute to vessel growth in the embryo and in
ischemic, malignant or inflammed tissues in the adult,
and can even be therapeutically used to stimulate vessel
growth in ischemic tissues.
publication.page.subject
Citation
item.page.embargo
Ir a EstadÃsticas
Sin licencia Creative Commons.