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Hypothalamic Crh/Avp, plasmatic glucose and lactate remain unchanged during habituation to forced exercise

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dc.contributor.authorToval, Angel
dc.contributor.authorVicente-Conesa, Francisco
dc.contributor.authorMartinez-Ortega, Paloma
dc.contributor.authorKutsenko, Yevenhiy
dc.contributor.authorMorales-Delgado, Nicanor
dc.contributor.authorGarrigos, Daniel
dc.contributor.authorAlonso Fuentes, Antonia
dc.contributor.authorFerrán Bertone, José Luis
dc.contributor.authorRibeiro do Couto, Bruno
dc.contributor.authorPopovic Popovic, Miroljub
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.date.accessioned2021-03-24T16:54:53Z
dc.date.available2021-03-24T16:54:53Z
dc.date.issued2020-05-15
dc.description.abstractIt has been demonstrated that physical activity contributes to a healthier life. However, there is a knowledge gap regarding the neural mechanisms producing these effects. One of the keystones to deal with this problem is to use training programs with equal loads of physical activity. However, irregular motor and stress responses have been found in murine exercise models. Habituation to forced exercise facilitates a complete response to a training program in all rodents, reaching the same load of physical activity among animals. Here, it was evaluated if glucose and lactate – which are stress biomarkers – are increased during the habituation to exercise. Sprague-Dawley rats received an 8-days habituation protocol with progressive increments of time and speed of running. Then, experimental and control (non-habituated) rats were subjected to an incremental test. Blood samples were obtained to determine plasmatic glucose and lactate levels before, immediately after and 30 min after each session of training. Crh and Avp mRNA expression was determined by two-step qPCR. Our results revealed that glucose and lactate levels are not increased during the habituation period and tend to decrease toward the end of the protocol. Also, Crh and Avp were not chronically activated by the habituation program. Lactate and glucose, determined after the incremental test, were higher in control rats without previous contact with the wheel, compared with habituated and wheel control rats. These results suggest that the implementation of an adaptive phase prior to forced exercise programs might avoid non-specific stress responses.es
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dc.identifier.citationHypothalamic Crh/Avp, Plasmatic Glucose and Lactate Remain Unchanged During Habituation to Forced ExerciseFront Physiol. 2020; 11: 410.
dc.identifier.doi10.3389/fphys.2020.00410
dc.identifier.urihttp://hdl.handle.net/10201/105605
dc.languageenges
dc.publisherFrontierses
dc.relationGranted by the Spanish Ministry of Science, Innovation and Universities and European Regional Development Fund (FEDER; PGC2018-098229-B-100 to JF), and by Séneca Foundation (19904/GERM/15).es
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fphys.2020.00410/fulles
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectrunning wheeles
dc.subjectstress response,es
dc.subjectfamiliarization,es
dc.subjectincremental test,es
dc.subjectmotor activity,es
dc.subjectparaventricular nucleus,es
dc.subjectstress biomarkerses
dc.subject.otherCDU::6 - Ciencias aplicadases
dc.titleHypothalamic Crh/Avp, plasmatic glucose and lactate remain unchanged during habituation to forced exercisees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicatione6582236-1657-4fd1-8c98-d549ab609b91
relation.isAuthorOfPublicationd6a86d85-30c4-4b1f-98f9-935d7b99b71f
relation.isAuthorOfPublicationeb9f6a5b-a801-4042-b976-4780e73c0e87
relation.isAuthorOfPublication43b53091-f5bf-4b46-b164-88d2a3670e2f
relation.isAuthorOfPublication.latestForDiscoverye6582236-1657-4fd1-8c98-d549ab609b91
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