Publication: Glycosylation and lectins-examples of
immunesurveillance and immune evasion
Authors
Müller, I. ; Jenner, J. ; Handgretinger, R. ; Riberdy, J. ; Kerst, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell surface proteins are posttranslationally
modified by tightly regulated enzymes of glycosylation.
Typical patterns of glycosylation may signal
pathological situations to the immune system. Here,
carbohydrate receptors on the surface of cells in the
immune system are involved in regulation of effector
cells. Moreover, some lectins are circulating in the
plasma and take part in host defense. The code of
carbohydrate modifications is impaired in malignant
cells and yet they are not eliminated. In this review, we
focus on recent experimental evidence for regulatory
functions of lectins and carbohydrate derivatives in the
immune system and tumours.
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Citation
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