Publication: Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney
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Date
2006
Authors
Kuroda, Naoto ; Hes, O. ; Miyazaki, E. ; Shuin, T. ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mucinous tubular and spindle cell carcinoma
(MTSCC) is a new tumorous entity which has been
recently established. In this article, we examined the
expression of neuroendocrine markers including neuron
specific enolase (NSE), chromogranin A and
synaptophysin in 16 cases of MTSCC using
immunohistochemistry. The sex ratio (male: female) of
the patients was 4:12. In normal kidney, distal tubules or
collecting ducts were positive for NSE, but no structures
were positive for chromogranin A or synaptophysin. All
MTSCCs showed a positive reaction for NSE.
Additionally, fifteen of sixteen neoplasms (93.8%) with
MTSCC showed the expression of either chromogranin
A or synaptophysin or both. Finally, it is possible that
MTSCC may be one of renal neoplasms which
frequently exhibit the neuroendocrine differentiation
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