Publication: Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance
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Date
2006
Authors
Zhao, P. ; Hou, N. ; Lu, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The FHIT gene encompassing the most
active common human fragile region, FRA3B, has been
proposed as a tumour suppressor gene for important
common human carcinomas. The mechanism in which
Fhit protein exerts its tumour suppressor activity is still
obscure. To further understand the Fhit function
associated with its intracellular localization we have
investigated its cellular localization and distribution in
human normal and cancerous tissues. Data of 1500
samples from immunohistochemistry showed that Fhit
protein was preferentially and stably expressed in the
nucleus of monocyte-derived or histiocytic lineage cells
including monocytes of the circulating blood cells,
macrophages of the connective tissue, Kupffer cells of
the liver, alveolar macrophages or dust cells of the lung,
osteoclasts of bone, microglia of the brain, epithelioid
cells under chronic inflammatory conditions, foreignbody
giant cells, Langerhans cells of the epidermis and
dendritic cells of various kinds of human tissue,
although the protein could also be infrequently observed
in the nucleus of some quiescent epithelial cells. In
active cells other than histiocytes, Fhit protein was
detected either in cytoplasm or was negative. Neurons
expressed Fhit strongly and neuroglial cells did so
moderately but only in the cytoplasm. There was no Fhit
protein detected in the neutrophils, lymphocytes, plasma
cells and lipocytes. The present data showes that the
stable nuclear localization of Fhit is not only a special
marker for histiocytes with various morphologies but
also may suggest the other function concerning Fhit as a
signaling molecule related to anti-proliferation function.
The detailed biological function related to nuclear
localization of Fhit protein in the histiocytes remains to
be further studied.
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