Publication:
Involvement of gap junctional communication and connexin expression in trophoblast differentiation of the human placenta

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dc.contributor.authorCronier, L.
dc.contributor.authorBastide, B.
dc.contributor.authorDefamie, N.
dc.contributor.authorNiger, C.
dc.contributor.authorPointis, G.
dc.contributor.authorGasc, J. M.
dc.contributor.authorMalassine, A.
dc.date.accessioned2020-09-04T15:02:07Z
dc.date.available2020-09-04T15:02:07Z
dc.date.issued2001
dc.description.abstractGap junctional intercellular communication (GJIC) permits coordinated cellular activities during development and d ifferentiation processes, and its dysfunction or mutation of connexin genes have been implicated in pathologies. In the human placenta, two distinct differentiation pathways of cytotrophoblastic cell coexist leading to a double model: fusion phenotype (villous trophoblast) a nd proliferative/ invasive phenotype (extravillous trophob last). This review focuses on current knowledge on the connexin expression and the implication of GJIC in trophoblastic differentiation. Experimental evidence obtained in human placenta demonstrates the involvement of connexin 43-gap junctions in the trophoblastic fusion process and of a connexin switch during the spatially and temporally controlled proliferation/invasion process.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology, Vol. 16, n.º 1 (2001)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/95715
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGap junctiones
dc.subjectConnexines
dc.subjectGIJCes
dc.subjectDifferentiationes
dc.subjectHuman trophoblastes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleInvolvement of gap junctional communication and connexin expression in trophoblast differentiation of the human placentaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.16, nº 1 (2001)