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Differences in life expectancy between men and women after aortic valve replacement

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dc.contributor.authorHernández Vaquero, Daniel
dc.contributor.authorRodríguez Caulo, Emiliano
dc.contributor.authorVigil Escalera, Carlota
dc.contributor.authorBlanco Herrera, Oscar
dc.contributor.authorBerastegui, Elisabet
dc.contributor.authorArias Dachary, Javier
dc.contributor.authorSouaf, Souhayla
dc.contributor.authorParody, Gertrudis
dc.contributor.authorLaguna, Gregorio
dc.contributor.authorAdsuar, Alejandro
dc.contributor.authorCastellá, Manuel
dc.contributor.authorValderrama, José F.
dc.contributor.authorPulitani, Ivana
dc.contributor.authorCánovas López, Sergio
dc.contributor.authorFerreiro, Andrea
dc.contributor.authorGarcía Valentín, Antonio
dc.contributor.authorCarnero, Manuel
dc.contributor.authorPareja, Pilar
dc.contributor.authorCorrales, José A.
dc.contributor.authorBlázquez, José A.
dc.contributor.authorMacías, Diego
dc.contributor.authorFletcher-Sanfeliu, Delfina
dc.contributor.authorMartínez, Daniel
dc.contributor.authorMartín, Elio
dc.contributor.authorMartín, Miren
dc.contributor.authorMargarit, Juan
dc.contributor.authorHernández Estefanía, Rafael
dc.contributor.authorMonguió, Emilio
dc.contributor.authorOtero, Juan
dc.contributor.authorSilva, Jacobo
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2024-07-18T08:30:55Z
dc.date.available2024-07-18T08:30:55Z
dc.date.issued2021-03-27
dc.description© The Author(s) 2021.This document is the Published version of a Published Work that appeared in final form in European Journal of Cardio-Thoracic Surgery. To access the final edited and published work see https://doi.org/10.1093/ejcts/ezab140
dc.description.abstractOBJECTIVES: Some researchers have observed an increased number of deaths during the follow-up of young patients who undergo aortic valve replacement due to severe aortic stenosis, suggesting that this procedure does not restore their life expectancy. Our goal was to confirm these findings and explore sex-based differences. METHODS: All patients between 50 and 65 years of age who underwent isolated aortic valve replacement in 27 Spanish centres during an 18-year period were included. We compared observed and expected survival at 15 years of follow-up and estimated the cumulative incidence of death from a competing risks point of view. We stratified by sex and analysed if being a woman was an independent risk factor for death. RESULTS: For men, the observed survival at 10 and 15 years of follow-up was 85% [95% confidence interval (CI) 83.6%–86.4%] and 72.3% (95% CI 69.7%–74.7%), respectively whereas the expected survival was 88.1% and 78.8%. For women, the observed survival at 10 and 15 years was 85% (95% CI 82.8%–86.9%) and 73% (95% CI 69.1%–76.4%), whereas the expected survival was 94.6% and 89.4%. At 15 years of follow-up, the cumulative incidence of death due to the disease in men and women was 8.2% and 16.7%, respectively. In addition, being a woman was an independent risk factor for death (hazard ratio = 1.23 (95% CI 1.02–1.48; P = 0.03). CONCLUSIONS: After the aortic valve replacement, men and women do not have their life expectancy restored, but this loss is much higher in women than in men. In addition, being a woman is a risk factor for long-term death. Reasons for these findings are unknown and must be investigated.es
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dc.identifier.citationEuropean Journal of Cardio-Thoracic Surgery 60 (2021) 681–688
dc.identifier.doihttps://doi.org/10.1093/ejcts/ezab140
dc.identifier.issnPrint: 1010-7940
dc.identifier.issnElectronic: 1873-734X
dc.identifier.urihttp://hdl.handle.net/10201/143182
dc.languageenges
dc.publisherOxford University Press
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://academic.oup.com/ejcts/article/60/3/681/6190381?login=true
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSevere aortic stenosises
dc.subjectAortic valve replacementes
dc.subjectExcess of mortalityes
dc.titleDifferences in life expectancy between men and women after aortic valve replacementes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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