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Stem cells: Are they the answer to the puzzling etiology of endometriosis?

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dc.contributor.authorOliveira, Flávia R.
dc.contributor.authorDela Cruz, Cynthia
dc.contributor.authorDel Puerto, Helen L.
dc.contributor.authorVilamil, Quésia T.M.F.
dc.contributor.authorReis, Fernando M.
dc.contributor.authorCamargos, Aroldo F.
dc.date.accessioned2017-03-07T19:26:46Z
dc.date.available2017-03-07T19:26:46Z
dc.date.issued2012
dc.description.abstractEndometriosis is a chronic bening disease characterizaed by the presence of abnormally located tissue resembling the endometrium with glands and stroma. This disease has a high degree of morbidity due to chronic pelvic pain and infertility. The disease is likely to be polygenic and multifactorial, but the exact pathogenic mechanisms are still not entirely clear. Recently, adult stem cells have been identified in several tissues, including the endometrium. These cells are probably involved in the regenerative ability of the endometrial cycle, and also in the pathogenesis of proliferative gynaecological diseases, such as endometriosis. The identification of stem cells in animal and human tissues is very complex and the putative stem cells are supposed to be found through several assays such as clonogenicity, label-retaining cells, “side- population” cells, undifferentiation markers, and cellular differentiation. Bone marrow-derived stem cells transplanted into humans and animals have also been identified in eutopic endometrium and endometriotic implants. This review evaluates the available evidence regarding stem/progenitor cells in the human endometrium and explores the possible involvement of these cells in the etiology of endometriosis.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 1 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52362
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEndometriumes
dc.subjectStem celles
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetriciaes
dc.titleStem cells: Are they the answer to the puzzling etiology of endometriosis?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 1 (2012)