Publication: Roles of integrins in fibronectin matrix assembly
Authors
Wu, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Fibronectin (Fn) matrix assembly is a
dynamic cellular process in which the soluble dimeric Fn
molecules are assembled into insoluble, disulfide bond
stabilized fibrillar polymeric matrix. Fn matrix assembly
requires specific Fn binding integrins. Several Fn
binding integrins that are capable of mediating Fn matrix
assembly have been identified. They include a5B1,
aIIbB3 and ctvB3 integrins. Cells regulate the matrix
assembly process not only by controlling cell surface
expression leve1 of the Fn binding integrins but also by
modulating Fn binding and cytoskeleton binding
activities of the integrins. A major challenge of future
studies is to delineate the signal transduction pathway
that regulates Fn matrix assembly
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