Publication: Environmental enrichment preserves hippocampal neurons in diabetes and stressed rats
Authors
Pamidi, N. ; Yap, C.G. ; Nayak, S.
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-418
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info:eu-repo/semantics/article
Description
Abstract
This study evaluated the effect of
Environmental Enrichment (EE) on neuron morphology
in the CA1, CA3 and dentate hilus (DH) regions of the
hippocampus by quantitating the total dendritic
arborizations. EE is a potential intervention for stress
and diabetes. It is capable of mitigating diabetes and
stress-induced cognitive and memory deficit. Diabetes
and stress were induced in male Wistar rats (4-5 weeks).
Diabetic and stressed rats were exposed to EE on Day 2
post STZ injection and subsequently once daily for 30
days. All animals were sacrificed on Day 30. The
hippocampus was dissected and processed for Golgi
staining to quantitate dendritic arborizations at the CA1,
CA2 and DH regions. Diabetes (D) and Diabetes+stress
(D+S) groups had significantly fewer apical and basal
dendritic branching points (ADBP, BDBP) at CA1
(p<0.01), CA3 (p<0.001) and DH (p<0.001) relative to
control group (NC). Diabetes and stressed rats exposed
to EE: [D+EE and D+S+EE groups] exhibited
significantly denser ADBP and BDBP at all regions
relative to D (p<0.001) and (D+S+EE) (p<0.001) groups
respectively. EE significantly preserved neuronal
arborizations in hippocampus of diabetic and stressed
rats, suggesting a potential entity of diabetes and stress
management.
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Citation
Histology and Histopathology Vol. 37, nº4 (2022)
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