Publication: Microglia – insights into immune system structure, function, and reactivity in the central nervous system
Authors
Wirenfeldt, Martin ; Babcock, Alicia A. ; Vinters, Harry V.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Microglia are essential cellular components
of a well-functioning central nervous system (CNS). The
development and establishment of the microglial
population differs from the other major cell populations
in the CNS i.e. neurons and macroglia (astrocytes and
oligodendrocytes). This different ontogeny gives
microglia unique properties. In recent years detailed
studies of the microglial population have been greatly
facilitated by the use of bone marrow (BM) chimeric
animals. Experimental BM transplants have provided the
opportunity to trace and investigate how BM cells
migrate into the CNS and settle to become microglia.
Furthermore various functional properties of microglia
in the normal and pathological CNS are now
being revealed because of combinations of BM
transplantations and experimental disease models. Here,
we describe some of the latest findings in microglial
biology and discuss the potential for using microglia in
therapeutic interventions.
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