Publication: Homeodomain proteins and eukaryotic translation initiation factor 4E (eIF4E): an unexpected relationship
Authors
Topisirovic, I. ; Borden, K.L.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The central role of post-transcriptional
modification of the expression of several genes involved
in tumorigenesis implicates eIF4E as a pivotal factor in
the regulation of cell survival, growth and proliferation.
Overexpression of eIF4E leads to malignant
transformation in vitro and induces tumor formation in
vivo. Furthermore, upregulated expression of eIF4E has
been reported in a variety of human malignancies.
Consequently, studies over the last ten years have sought
to better characterize the molecular mechanisms and
cellular factors that control eIF4E activity. These efforts
have revealed a role for eIF4E in diverse biological
processes including embryonic development, cell cycle
progression, synaptic plasticity and cancer. In this
review we focus on several members of the
homeodomain protein family, which have recently been
identified as a novel class of eIF4E regulators.
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