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Clinicopathological diagnosis of axillary signet-ring cell-like/histiocytoid carcinoma: A case report and literature review

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dc.contributor.authorZhang, Ling
dc.contributor.authorLi, Li
dc.contributor.authorWang, Yun
dc.contributor.authorWang, Xiao ling
dc.date.accessioned2025-05-13T08:02:03Z
dc.date.available2025-05-13T08:02:03Z
dc.date.issued2025
dc.description.abstractObjective. To explore the clinicopathological and morphological characteristics, diagnosis, differential diagnosis, treatment, and prognosis of primary signet-ring cell/histiocytoid carcinoma (SRCHC) of the axilla. Methods. The clinical manifestations, patho-morphological characteristics, and immunohistochemical staining results of a case of primary SRCHC in the axilla were retrospectively analyzed, and the relevant literature was reviewed. Results. The patient was a 69-year-old male. Subcutaneous gray-white nodules with unclear boundaries were visible. Microscopic examination: The tumor was located in the dermis and subcutaneous tissue. The tumor cells were arranged in a cord-like, soldier-like, or nest-like shape, with mild to moderate atypia. Some cells had obvious nucleoli. The tumor cytoplasm was eosinophilic, and mucoid material inside and outside the cells could be seen, showing a signet-ring-like or histiocytoid appearance. Immunohisto-chemical staining was positive for GCDFP-15, CK7, E-cadherin, AR, P120, GATA3 and negative for Villin, S-100, CK20, SMA, P63, CD68, TTF-1, NapsinA, ER, PR, and Ki-67 proliferation index (8%), HER2(2+) and FISH(-). The special staining AB-PAS (AB+,PAS-). Conclusion. Cutaneous axillary primary SRCHC is extremely rare and highly invasive and needs to be differentiated from a variety of metastatic tumors (breast, digestive system, lung, etc.).es
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dc.format.extent7es
dc.identifier.citationHistology and Histopathology Vol. 40, nº06 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-828
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/154395
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAxillaes
dc.subjectSignet ring cell-like/histiocytoides
dc.subjectPrimaryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleClinicopathological diagnosis of axillary signet-ring cell-like/histiocytoid carcinoma: A case report and literature reviewes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº6 (2025)