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Studies on the involvement Histology and Histopathology Cellular and Molecular Biology of endogenous neuropeptides in the control of thymocyte proliferation in the rat

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dc.contributor.authorTrejter, M.
dc.contributor.authorWarchol, J. B.
dc.contributor.authorde Caro, R.
dc.contributor.authorBrelinska, R.
dc.contributor.authorNussdorfer, G. G.
dc.contributor.authorMalendowicz, L. K.
dc.date.accessioned2020-09-04T14:19:32Z
dc.date.available2020-09-04T14:19:32Z
dc.date.issued2001
dc.description.abstractThe possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation ha s been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors of the three neuropeptides on the mitotic index (%0 of metaphase-arrested cells after vincristin injection) of thymocytes. Both CCK- and TN-receptor antagonists were ineffective. In contrast, two VIP receptor antago nists (VIP-As) enhanced the mitotic index of thymocytes. VIP reversed the effect of VIP-As, but when administered alone it did not alter the mitotic activity of thymocytes. In light of these findings, we conclude that endogenous VIP exerts a maximal tonic inhibitory influence on the basal proliferative activity of rat thymocytes, while endogenous CCK and NT do not play a relevant modulatory role in thi process.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.citationHistology and Histopathology, Vol. 16, n.º1 (2001)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/95712
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectThymuses
dc.subjectCell proliferationes
dc.subjectVasoactive intestinal peptidees
dc.subjectCholecystokinines
dc.subjectNeurotensines
dc.subjectRates
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleStudies on the involvement Histology and Histopathology Cellular and Molecular Biology of endogenous neuropeptides in the control of thymocyte proliferation in the rates
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.16, nº 1 (2001)