Publication: Effects of unilateral cervical vagotomy on antral endocrine cells in mouse
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Date
1999
Authors
Qian, B.F. ; El-Salhy, M. ; Danielsson, A. ; Shalaby, A. ; Axelsson, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study was carried out to
investigate the effect of unilateral cervical vagotomy on
the antral endocrine cells in mouse. Fifty-four mice were
randomly divided into three groups, 18 in each, for left
or right cervical vagotomy, or sham operation as
controls. The animals were sacrificed 2, 4, and 8 weeks
after the operation, respectively. Chromogranin-,
gastrin/CCK-, serotonin-, and somatostatin-cells were
detected by immunohistochemistry and quantitated by
computerised image analysis. The results showed that
the number of chromogranin-cells was decreased in both
left and right vagotomized mice after 4 weeks and
remained at the same level after 8 weeks. The numbers
of gastrin-, serotonin- and somatostatin-cells did not
change after right vagotomy. However, the numbers of
gastrin- and somatostatin-cells were decreased after left
vagotomy, whereas no change was found in serotonincells.
Endocrine cells with vacuolated cytoplasm and
pyknotic nuclei were also observed during the course of
time. The alteration in the antral endocrine cells
observed in this study seemed to be dynamic and
depended on the observation time after the operation as
well as the denervated branches of the vagus nerve. This
may explain, at least partially the contradictory results
obtained earlier by different investigators.
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