Publication: Expression of HBsAg and HBsAg in liver tissue, correlation with disease activity
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Date
1992
Authors
Nakopoulou, Lydia ; Adraskelas, N. ; Stefanak, K. ; Zacharoulis, D. ; Hadziyanni, St.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The pattems of Hepatitis B surface antigen
(HBsAg) and Hepatitis B core antigen (HBcAg)
expression were studied in liver biopsies taken from 41
patients with chronic HBV disease. Immunohistochemical
methods were used on deparaffinized
sections for the identification of HBsAg and HBcAg in
liver tissue.
lkenty-one of the 41 cases (5 1.2%) were classified as
inactive liver disease and 20 (48.8%) as active liver
disease. In liver biopsies with inactive disease, HBsAg
demonstrated varying types of cytoplasmic expression in
a rather high number of hepatocytes distributed mainly in
clusters, while HBcAg was rarely expressed in liver
nuclei. On the other hand, in liver biopsies with active
disease HBsAg was characterized by a diffuse cytoplasmic
expression in a few discrete hepatocytes, while HBcAg
was expressed in the nuclei of the hepatocytes in 70% of
the cases and in half of the positive cases it was also
detected in the cytoplasm.
In conclusion, HBsAg expression in a few scattered
hepatocytes correlates with active liver disease and
positive HBcAg, while varying HBsAg cytoplasmic
expression in a rather high number of clustered
hepatocytes is related to chronic inactive liver disease and
negative expression of HBcAg.
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