Publication: Hepatic alterations and induction of micronuclei in rainbow trout Oncorhynchus mykiss exposed to a textile industry effluent
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Date
1998
Authors
Marlasca, M.J. ; Sanpera, C. ; Riva, M.C. ; Sala, R. ; Crespo, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Rainbow trout, Oncorhynchus mykiss, were
exposed to a sublethal dose of a wool shrinkproofing
effluent for 15, 30, 45 and 60 days. Liver and blood
samples were taken after the exposure time together with
samples of control handled fish. A light and electron
microscope study was carried out to evaluate the histopathological
lesions induced in the liver of treated fish.
The genotoxic potential of the effluent was assessed by
piscine micronucleus test. Vacuolation of liver bile preductular
cells was observed in all exposed fish; abnormal
lipid accumulation and basophilic foci were seen in the
liver of one 30-days- and one 45-days-exposed fish,
respectively. These specific alterations could be related
to a pre-carcinogenic process. On the contrary, other
lesions also described in all treated fish such as
dilatation, vesiculation and degranulation of the rough
endoplasmic reticulum, altered mitochondria, increase in
myelin bodies and lysosomes and presence of phagosomes
in wandering macrophages might be considered
as non-specific alterations, similar to those described in
fish exposed to different pollutants. Frequencies of
micronucleated peripheral erythrocytes showed a
significant increase following 30-days exposure.
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