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Morphometric study of uninvolved rectal mucosa 10 cm and 20 cm away from the malignant tumor

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dc.contributor.authorDespotović, Sanja Z.
dc.contributor.authorMilicevic, Novika M.
dc.contributor.authorMilošević, Dragoslav P.
dc.contributor.authorDespotović, Nebojša
dc.contributor.authorErceg, Predrag
dc.contributor.authorBojic, Božidar
dc.contributor.authorBojić, Danijela
dc.contributor.authorSvorcan, Petar
dc.contributor.authorMihajlović, Gordana
dc.contributor.authorDordević, Jelena
dc.contributor.authorLalić, Ivana M.
dc.contributor.authorMilicevic, Živana
dc.date.accessioned2019-01-15T15:11:41Z
dc.date.available2019-01-15T15:11:41Z
dc.date.issued2014
dc.description.abstractRecently, many details of the interplay between tumor cells and tumor-associated stromal elements leading to the progression of malignant disease were elucidated. In contrast, little is known about the role of uninvolved stromal tissue in the remote surrounding of the malignant tumor. Therefore, we performed a computer-aided morphometric study of rectal mucosa in samples taken 10 cm and 20 cm away from the malignant tumor during endoscopic examination of 23 patients older than 60 years. The samples of rectal mucosa from 10 healthy persons of corresponding age subjected to diagnostic rectoscopy during active screening for asymptomatic cancer were used as control. All structural elements of the rectal mucosa were studied and the number of nucleated cells in the lamina propria per 0.1 mm2 of tissue was assessed. Our study revealed a reduced number of cells in the lamina propria of the rectal mucosa 10 cm and 20 cm away from the tumor lesion in both male and female patients. The decreased mucosal height and increased crypt number were registered in female patients 10 cm away from the tumor. The connective tissue of lamina propria showed a disorderly organization: the collagen fibers were frail, loosely arranged and signs of tissue edema were present. Small blood vessels and capillaries were much more frequently seen than in healthy tissue. Our results demonstrate the complex interactions between the cancer and remote mucosal tissue of the affected organ.es
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dc.format.extent6es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 2 (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/66440
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectComputer-Assisted Image Analysises
dc.subjectRectumes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleMorphometric study of uninvolved rectal mucosa 10 cm and 20 cm away from the malignant tumores
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 2 (2014)