Publication: Malignant transformation of nasal chondromesenchymal hamartoma in adult:
a case report and review of the literature
Authors
Li, Yang ; Yang, Qing-xu ; Tian, Xiao-ying ; Li, Bin ; Li, Zhi
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Nasal chondromesenchymal hamartoma
(NCMH) is an extremely rare benign tumor arising in
the sinonasal tract, predominantly involving infants and
children. To date, only 27 cases are reported in the
international literature and there have been no reported
cases of malignant transformation. We present a 40-yearold
female patient with nasal obstruction and bloody
rhinorrhea. Computed tomography (CT) of the nose and
paranasal sinuses confirmed a heterogeneous polypoid
soft-tissue mass filling the nasal cavity and extending
into the maxillary and ethmoid sinus. The patient
underwent a complete radical resection. Histological and
immunohistochemical analyses showed a portion of the
mass was consistent with typical NCMH. However,
some areas of mass exhibited cytological atypia, marked
mitotic activity and foci of necrosis. The atypical
mesenchymal spindle cells were immunoreactive for
vimentin, CD99 and smooth muscle actin (SMA)
diffusely. The cartilaginous cells were immuno-positive
for S-100 protein. Ki-67 index was high in atypical
areas, accounting for 50%. A rapid mass recurrence was
observed at the original site only 3 months after surgery.
The final diagnosis of NCMH with malignant
transformation was made. To our knowledge, this is the
first report of malignant transformation occurring in an
adult with NCMH. Although NCMH commonly
develops in the neonate or young infants and exhibits
benign histological appearance and favorable prognosis,
there is a possibility of malignant transformation in adult
patients. Thoroughly histological inspections are
suggested to be necessary to accurately diagnose this
tumor when it is encountered in adults
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Citation
Histology and histopathology, Vol. 28, n.º 3 (2013)
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