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MCC950 closes the active conformation of NLRP3 to an inactive state

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dc.contributor.authorAngosto-Bazarra, Diego
dc.contributor.authorMartínez-Banaclocha, Helios
dc.contributor.authorTorre-Minguela, Carlos de
dc.contributor.authorCerón-Carrasco, Jose P
dc.contributor.authorPérez-Sánchez, Horacio
dc.contributor.authorArostegui, Juan I
dc.contributor.authorPelegrín Vivancos, Pablo
dc.contributor.authorTapia Abellán, Ana
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2025-01-20T12:46:32Z
dc.date.available2025-01-20T12:46:32Z
dc.date.issued2019-06
dc.description© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nature Chemical Biology. To access the final edited and published work see https://doi.org/10.1038/s41589-019-0278-6es
dc.description.abstractNLRP3 is an innate immune sensor contributing to the development of different diseases including monogenic autoinflammatory syndromes, gout, atherosclerosis, and Alzheimer’s disease. The molecule sulfonylurea MCC950 is a NLRP3 inflammasome inhibitor with potential clinical utility. However, the mechanism of action of MCC950 remains unknown. Here, we characterize the mechanism of action of MCC950 in both wild-type and autoinflammatory-related NLRP3 mutants, demonstrating that MCC950 closes the ‘open’ conformation of active NLRP3.es
dc.formatapplication/pdfes
dc.format.extent37es
dc.identifier.citationNature Chemical Biology, 2019, Vol. 15, pp. 60-564
dc.identifier.doihttps://doi.org/10.1038/s41589-019-0278-6
dc.identifier.issnPrint: 1552-4450
dc.identifier.issnElectronic: 1552-4469
dc.identifier.urihttp://hdl.handle.net/10201/148834
dc.languageenges
dc.publisherNature Research
dc.relationThis work was supported by grants from the Instituto Salud Carlos III-Fondo Europeo de Desarrollo Regional (PI13/00174 to P.P.), the Ministerio de Economia, Industria y Competitividad–Fondo Europeo de Desarrollo Regional (project nos. SAF2017-88276-R to P.P. and CTQ2017-87974-R to H.P.-S.), Fundación Séneca (20859/PI/18 to P.P.), and the European Research Council (ERC-2013-CoG 614578 to P.P.).es
dc.relation.publisherversionhttps://www.nature.com/articles/s41589-019-0278-6es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNLRP3es
dc.subjectInflammationes
dc.subjectMCC950es
dc.subjectMechanism of actiones
dc.subjectAntiinflammatoryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiologíaes
dc.titleMCC950 closes the active conformation of NLRP3 to an inactive statees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
relation.isAuthorOfPublication0ef289d2-ad85-4d81-a66c-82879daf26a9
relation.isAuthorOfPublication.latestForDiscovery547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
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