Publication: Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer
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Date
2007
Authors
Liao, J.D. ; Adsay, N.V. ; Khannani, F. ; Grignon, D. ; Thakur, A. ; Sarkar, F.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Although pancreatic cancer is the fourth
leading cause of cancer death, it has received much less
attention compared to other malignancies. There are
several transgenic animal models available for studies of
pancreatic carcinogenesis, but most of them do not
recapitulate, histologically, human pancratic cancer.
Here we review some detailed molecular complexity of
human pancreatic cancer and their reflection in
histomorphological complexities of pancreatic lesions
developed in various transgenic mouse models with a
special concern for studying the effects of
chemotherapeutic and chemopreventive agents. These
studies usually require a large number of animals that are
at the same age and gender and should be either
homozygote or heterozygote but not a mixture of both.
Only single-transgene models can meet these special
requirements, but many currently available models
require a mouse to simultaneously bear several transgene
alleles. Thus it is imperative to identify new gene
promoters or enhancers that are specific for the ductal
cells of the pancreas and are highly active in vivo so as
to establish new single-transgene models that yield
pancreatic ductal adenocarcinomas for chemotherapeutic
and chemopreventive studies
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