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Salivary gland bioengineering - yesterday, today, tomorrow!

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dc.contributor.authorIyer, Janaki
dc.contributor.authorPillai, Sangeeth
dc.contributor.authorMunguia Lopez, Jose G.
dc.contributor.authorZhang, Yuli
dc.contributor.authorMielkozorova, Mariia
dc.contributor.authorTran, Simon D.
dc.date.accessioned2023-05-24T10:23:26Z
dc.date.available2023-05-24T10:23:26Z
dc.date.issued2023
dc.description.abstractSalivary glands are specialized structures developed as an extensively compact, arborized design through classical embryogenesis, accompanied by a cascade of events channelized by numerous growth factors and genetic regulatory pathways. Salivary secretions maintain oral homeostasis and, when diminished in certain conditions, present as xerostomia or salivary hypofunction, adversely impacting the patient’s quality of life. The current available treatments primarily aim at tackling the immediate symptoms providing temporary relief to the patient. Despite scientific efforts to develop permanent and effective solutions to restore salivation, a significant permanent treatment is yet to be established. Tissue engineering has proven as a promising remedial tool in several diseases, as well as in xerostomia, and aims to restore partial loss of organ function. Recapitulating the physiological cellular microenvironment to in vitro culture conditions is constantly evolving. Replicating the dynamic multicellular interactions, genetic pathways, and cytomorphogenic forces, as displayed during salivary gland development have experienced considerable barriers. Through this review, we endeavour to provide an outlook on the evolution of in vitro salivary gland research, highlighting the key bioengineering advances and the challenges faced with the current therapeutic strategies for salivary hypofunction, with an insight into our team’s scientific contributions.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationHistology and Histopathology Vol. 38, nº6 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-580
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/131404
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSalivary glandes
dc.subjectXerostomíaes
dc.subjectRegenerationes
dc.subjectBioengineeringes
dc.subjectGene therapyes
dc.subject3D culturees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleSalivary gland bioengineering - yesterday, today, tomorrow!es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº6 (2023)