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Cardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys.

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dc.contributor.authorAlmela, Pilar
dc.contributor.authorCuenca Bermejo, Lorena
dc.contributor.authorYuste, José E.
dc.contributor.authorEstrada, Cristina
dc.contributor.authorPablos, Vicente de
dc.contributor.authorBautista Hernández, Víctor
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorLaorden Carrasco, María Luisa
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.contributor.departmentMedicina Interna
dc.date.accessioned2024-02-09T12:00:14Z
dc.date.available2024-02-09T12:00:14Z
dc.date.issued2019-11
dc.description©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Movement Disorders. To access the final edited and published work see https://doi.org/10.1002/mds.27958es
dc.description.abstractABSTRACT: Background: Autonomic dysfunction is a well-known dominant symptom in the advanced stages of Parkinson’s disease. However, the role of cardiac sympathetic nerves still needs to be elucidated. Objectives: To evaluate cardiac sympathetic response in Parkinsonian and dyskinetic monkeys. Methods: Adult male monkeys were divided into 1 of the following 3 groups: controls, 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine–treated monkeys, and 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine+levodopa–treated animals. Noradrenaline, its metabolite normetanephrine, and phospho-Heat shock proten 27 (p-Hsp27) at erine 82 levels were analyzed in the left and right ventricles of the heart. Tyrosine hydroxylase immunohistochemistry was performed in the ventral mesencephalon. Results: The results were the following: (1) 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine intoxication significantly increased normetanephrine levels and decreased noradrenaline turnover in the right ventricle without changes in the left ventricle; however, (2) levodopa treatment decreased noradrenaline levels and enhanced the normetanephrine/noradrenaline ratio in parallel with a very significant increase of Hsp27 activity in both ventricles. Conclusions: Levodopa treatment could induce protective cardiac effects through the increased Hsp27 activity. © 2019 International Parkinson and Movement Disorder Societyes
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.citationMovement Disorders (2019)
dc.identifier.doi10.1002/mds.27958
dc.identifier.issn0885-3185
dc.identifier.issn1531-8257
dc.identifier.urihttp://hdl.handle.net/10201/139115
dc.languageenges
dc.publisherWiley Online Libraryes
dc.relationFunding agencies: This work was supported by grants from the Spanish Ministry of Science (SAF 2007-62262; SAF/FEDER2013-49076-P; FIS PI1002827) and Fundación Séneca (FS/15329/PI/10).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHsp27es
dc.subjectL-dopaes
dc.subjectNA turnoveres
dc.subjectParkinson’s diseasees
dc.subjectTHes
dc.subject.odsObjetivo 3: Salud
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleCardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication9bbe7af5-429b-4029-b621-0399a6838322
relation.isAuthorOfPublication072da45c-404e-4559-a637-6e8df94220c7
relation.isAuthorOfPublicationa28169ff-757a-4fa6-a2c9-687ece58e422
relation.isAuthorOfPublication.latestForDiscovery9bbe7af5-429b-4029-b621-0399a6838322
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