Publication: Innervation of the canine mammary gland: an immunohistochemical study
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Date
2007
Authors
Pinho, M.S. ; Gulbenkian, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The distribution of peptidergic nerves in
canine mammary tissues was studied by
immunohistochemical techniques. In addition, the
general and the noradrenergic innervations were
demonstrated using protein gene product 9.5 and
tyrosine hydroxylase immunoreactivities as markers,
respectively. Tissue specimens from the caudal
mammary glands were obtained from adult, nonlactating,
female dogs. The overall innervation of the
mammary gland tissue was sparse and primarily
associated with the arterial vasculature. Nerve fibres
positive for protein gene product 9.5 were rarely found
in the secretory parenchyma. The nipple was not richly
innervated, although it displayed a greater amount of
nerve fibres than the mammary parenchyma. Nerve
fibres supplying nonvascular structures of the nipple
expressed immunoreactivity for the sensory
neuropeptides calcitonin gene-related peptide, substance
P and neuropeptide K, but not for vasoactive intestinal
peptide, peptide histidine isoleucine and C-flanking
peptide of neuropeptide Y. Somatostatin
immunoreactivity was not detected in mammary gland
tissue. Our results indicate that the innervation of the
canine mammary gland is mainly affiliated with the
vasculature and comprises peptidergic nerves which may
be involved in the regulation of local blood flow. The
presence of sensory neuropeptides in nerves supplying the mammary nipple suggest that these peptides may
play a role in the afferent pathway of the milk ejection
reflex.
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