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CircRIP2 promotes NSCLC progression by sponging for miR-671-5p to regulate FOXM1 expression

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dc.contributor.authorLiu, Yizhi
dc.contributor.authorFeng, Xing
dc.contributor.authorKang, Shuhong
dc.contributor.authorLv, Feng
dc.contributor.authorNi, Yunfeng
dc.contributor.authorWu, Hua
dc.date.accessioned2023-02-09T11:11:02Z
dc.date.available2023-02-09T11:11:02Z
dc.date.issued2022
dc.description.abstractLot of attention had been paid to the role of circular RNAs (circRNAs) in carcinogenesis recently. However, knowledge about circRNAs in NSCLC development is far from satisfactory. In this study, we aimed to provide a novel insight into the circRIP2 in NSCLC development. We used NSCLC tissues, as well as cell lines to elucidate the expression and location of circRIP2 in NSCLC. We also established the circRIP2 overexpression cells A549-circRIP2 and repression cells HCC827-shcircRIP2 for further functional and mechanism studies. The pro-tumorigenic role of circRIP2 was tested by using CCK-8, BrdU and transwell assays. The interaction between circRIP2 and miR-671-5p were validated by luciferase reporter assay, RIP assay, as well as RNA pull down assay. We showed circRIP2 is differentially expressed NSCLC, and acted as a predictor for overall survival (OS) and disease-free survival (DFS). CircRIP2 promoted NSCLC progression by acting as a miRNA sponge for miR-671-5p, thus facilitating its target gene FOXM1 expression. Targeting circRIP2 could be potentially beneficial for NSCLC patients in the futurees
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 37, nº2 (2022)
dc.identifier.doihttps://doi.org/10.14670/HH-18-360
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128312
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNSCLCes
dc.subjectcircRIP2es
dc.subjectmiR-671-5pes
dc.subjectFOXM1es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCircRIP2 promotes NSCLC progression by sponging for miR-671-5p to regulate FOXM1 expressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37, nº2 (2022)