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Oral and dental sequelae after oncological treatment in children: a systematic review

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dc.contributor.authorTorrecillas Quiles, Lidia
dc.contributor.authorGómez Ríos, Inmaculada
dc.contributor.authorJiménez García, Irene
dc.contributor.authorSerrano Belmonte, Ildefonso
dc.contributor.authorOrtiz Ruiz, Antonio José
dc.contributor.authorSerna Muñoz, Clara
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-02-03T07:48:10Z
dc.date.available2026-02-03T07:48:10Z
dc.date.copyright© 2025 by the authors
dc.date.issued2025-08-04
dc.description.abstractBackground: Childhood cancer is considered one of the main causes of mortality and morbidity worldwide. There is strong evidence of the oral toxic effects of oncologic treatments, but their incidence is difficult to determine. The novel therapeutic strategies in Pediatric Oncology have led to increased survival in this population, resulting in an increased incidence of long-term effects, which diminish the patient’s quality of life. Methods: The search for articles started on 5 November 2024 and ended on 5 December 2024. Following the PRISMA Statement, a total of 1266 articles were obtained, from which 13 were selected for review. All articles were considered to be of high quality. The antineoplastic treatments used in them were chemotherapy, radiotherapy, surgery and immune therapy. Results: Most articles were cohorts and case controls. Only one case report was obtained. The results revealed that the most prevalent sequelae in the pediatric population after antineoplastic treatment were enamel alterations, microdontia, dental caries, periodontal disease, gingivitis, hyposalivation, alteration of the oral microbiome, alteration of mandibular bone density and malocclusion. The lesions are different depending on the therapy used. Conclusions: Oncologic treatments in children with cancer cause multiple oral sequelae such as microdontia, dental caries, enamel alterations, salivary gland alterations, mucositis and root resorption. It cannot be concluded which therapy has the most detrimental effect as each has a different mechanism of action in the oral cavity
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dc.identifier.citationTorrecillas-Quiles, L.; Gómez-Ríos, I.; Jiménez-García, I.; Serrano-Belmonte, I.; Ortiz-Ruiz, A.J.; Serna-Muñoz, C. Oral and Dental Sequelae After Oncological Treatment in Children: A Systematic Review. J. Clin. Med. 2025, 14, 5479. https:// doi.org/10.3390/jcm14155479
dc.identifier.doihttps://doi.org/10.3390/jcm14155479
dc.identifier.eissn2077-0383
dc.identifier.urihttp://hdl.handle.net/10201/198349
dc.languageeng
dc.publisherMDPI
dc.relationSin financiación externa a la Universidad
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/14/15/5479
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSystematic review
dc.subjectDental sequelae
dc.subjectOncological treatment
dc.subjectChildhood cancer
dc.subject.odsObjetivo 3: Salud
dc.titleOral and dental sequelae after oncological treatment in children: a systematic review
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublicationc42f35e8-5f95-4c41-b084-a18ea989caea
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relation.isAuthorOfPublication.latestForDiscoveryc42f35e8-5f95-4c41-b084-a18ea989caea
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