Publication:
Angiosarcomas: histology, immunohistochemistry and molecular insights with implications for differential diagnosis

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Machado-36-3-18-2021.pdf(17.91 MB)
Date
2021
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Authors
Machado, Isidro ; Giner, Francisco ; Lavernia, Javier ; Cruz, Julia ; Traves, Víctor ; Requena, Celia ; Llombart, Beatriz ; López Guerrero, José Antonio ; Llombart Bosch, Antonio
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-18-246
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info:eu-repo/semantics/article
Description
Abstract
Angiosarcomas (AS) represent a heterogenous group of tumors with variable clinical presentation. AS share an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging, especially in poorly-differentiated tumors. Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. In this review, we discuss pathological and molecular insights with emphasis on implications for differential diagnosis in cutaneous, breast, soft tissue and visceral AS.
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Angiosarcomas , Immunohistochemistry , Molecular biology , Differential diagnosis
Citation
Histology and Histopathology, Vol.36, nº1, (2021)
URI
http://hdl.handle.net/10201/126183
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Histology and histopathology Vol.36, nº1 (2021)
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