Publication: Tenascin and type IV collagen expression in
liver cell dysplasia and in hepatocellular carcinoma
Authors
Zhao, M. ; Laissue, J.A. ; Zimmermann, Astrid
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The extracellular matrix (ECM) located in
and around tumors is different from normal organ
stroma, and there is evidence that it is critically involved
in carcinogenesis and malignant growth. Whereas an
abnormal composition of ECM in hepatocellular
carcinomas (HCC's) has previously been demonstrated,
not much is known so far with respect to putative HCC
precursor lesions. We have, therefore, systematically
analyzed the immunohistochemical reactivity for two
major ECM components, tenascin and type IV collagen,
in three types of liver cell dysplasia (LCD), and
compared the findings with patterns observed in HCC's
of different types and grades. Tenascin reactivity was
generally stronger in HCC's than in cirrhosis. In
cirrhotic nodules harboring areas of LCD, tenascin
expression was significantly lower in small cell LCD
than in large cell LCD. Type IV collagen reactivity in
and around HCC's decreased as a function of a lower
differentiation grade. In both groups of cirrhosis, ¡.e.
with or without HCC, cirrhotic nodules occupied by the
small cell variant of LCD exhibited a significantly lower
type IV collagen reactivity than those with large cell
LCD or simple regenerative cells. Taken together these
findings suggest that, similar to adenomatous
hyperplasia, small cell LCD is characterized by an
abnormal tenascin and type IV collagen expression, thus
reflecting the defective ECM pattern observed in HCC's.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.