Biosynthesis of a novel polymeric chitosan-betaxanthin and characterization of the first sugar-derived betalains and their effects in the in vivo model Caenorhabditis elegans

Guerrero Rubio, María Alejandra; Hernández García, Samanta; Gandía Herrero, Fernando; García Carmona, Francisco

Publication:
Biosynthesis of a novel polymeric chitosan-betaxanthin and characterization of the first sugar-derived betalains and their effects in the in vivo model Caenorhabditis elegans

dc.contributor.author	Guerrero Rubio, María Alejandra
dc.contributor.author	Hernández García, Samanta
dc.contributor.author	Gandía Herrero, Fernando
dc.contributor.author	García Carmona, Francisco
dc.contributor.department	Bioquímica y Biología Molecular "A"
dc.date.accessioned	2025-05-28T10:47:23Z
dc.date.available	2025-05-28T10:47:23Z
dc.date.issued	2020-09-28
dc.description	© 2020 Elsevier Ltd. All rights reserved.This document is the Published version of a Published Work that appeared in final form in Carbohydrate Polymers. To access the final edited and published work see https://doi.org/10.1016/j.carbpol.2020.117141	es
dc.description.abstract	Betaxanthins are nitrogenous plant pigments belonging to the family of betalains and they are known for their health-promoting effects and fluorescent properties. A novel biotechnological approach in the synthesis of these compounds has allowed the synthesis of high amounts of known betalains and of novel, tailor-made betalains through the condensation of the structural unit - betalamic acid - with amine groups of different compounds. Here we describe the synthesis and characterization of chitosan-betaxanthin, the first fluorescent polymeric betaxanthin which forms nanoparticles and that might combine the fluorescent properties of betalains and the properties of chitosan, a sugar polymer widely used with medical purposes. In addition, glucosamine, the structural unit of chitosan, and its stereoisomer galactosamine were shown to condense in solution with betalamic acid. This produced novel molecules with spectral and in vivo antioxidant and anti-aging properties similar to those of biological betaxanthins, which are the first sugar-derived betaxanthins described.	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	Carbohydrate Polymers 252 (2021) 117141
dc.identifier.doi	https://doi.org/10.1016/j.carbpol.2020.117141
dc.identifier.issn	Print: 0144-8617
dc.identifier.issn	Electronic: 1879-1344
dc.identifier.uri	http://hdl.handle.net/10201/155283
dc.language	eng	es
dc.publisher	Elsevier
dc.relation	This work was supported by the Spanish Ministry of Science and Innovation, project AGL2017-86526-P (MCI/AEI/FEDER, UE) and by the ?Programa de Ayudas a Grupos de Excelencia de la Región de Murcia, Fundaci?n S?neca, Agencia de Ciencia y Tecnolog?a de la Regi?n de Murcia (Spain)? (Project 19893/GERM/15). M.A.G.-R. holds a contract financed by MEC-FSE (Spain). S. H.-G. holds a contract financed by Fundación Séneca (Spain).	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S014486172031314X?via%3Dihub
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Betalains	es
dc.subject	Biocompatible	es
dc.subject	Carbohydrate	es
dc.subject	Fluorescence	es
dc.subject	Nanoparticles	es
dc.subject	Polymer	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica	es
dc.title	Biosynthesis of a novel polymeric chitosan-betaxanthin and characterization of the first sugar-derived betalains and their effects in the in vivo model Caenorhabditis elegans	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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