Publication: Steroid receptors ERa, ERß, PR-A and PR-B are differentially expressed in normal and atrophic human endometrium
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Date
2012-05-21
Authors
Mylonas, I. ; Jeschke, U. ; Shabani, N. ; Kuhn, C. ; Kunze, Sussane ; Dian, D. ; Friedl, C. ; Kupka, M.S. ; Friese, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective: The endometrium expresses
estrogen (ER) and progesterone receptor (PR), which are
related to autocrine and paracrine processes that respond
to estrogen and progesterone. Therefore, the aim of this
study was to evaluate the distribution pattern of ERa,
ERß, PR-A and PR-B with monoclonal antibodies in
normal human endometrial tissue. Study Design: Human
endometrial tissue was obtained from 84 premenopausal
and 11 postmenopausal patients and immunohistochemically
analysed with monoclonal antibodies
against ERa, ERß, PR-A and PR-B. Results: ERa, PR-A
and PR-B declined significantly (p<0.001, p<0.05,
p<0.05 respectively) in glandular epithelium from
proliferative to late secretory phase. The ERß
immunohistochemical reaction showed a similar
significant declining pattern (p<0.05), although the
staining intensity was lower than that of ERa. While
ERa, ERß and PR-B decrease significantly in atrophic
endometrial tissue compared to proliferative
endometrium, a significant up-regulation of PR-A was
observed compared to late secretory phase (p<0.05).
Conclusion: ERa, ERß, PR-A and PR-B were expressed
in normal human endometrium with a cyclical variation
during the menstrual cycle. In normal postmenopausal
endometrial tissue, a down-regulation of ERa, ERß and
PR-B occurs with a subsequent higher expression of PRA.
These results show the presence of steroid receptors
in human epithelium, indicating that these cells respond to estrogen and progesterone, thus playing a significant
role in endometrial physiology.
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