Publication: Relationship between human pupillary light reflex and circadian system status
Authors
Hild, Konstanze ; Isherwood, Cheryl ; Sweeney, Stephen J. ; Revell, Victoria L. ; Skene, Debra J. ; Rol, Maria Ángeles ; Madrid, Juan Antonio ; Bonmatí Carrión, María de los Ángeles
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Publisher
Public Library of Science
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DOI
https://doi.org/10.1371/journal.pone.0162476
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info:eu-repo/semantics/article
Description
© 2016 Bonmati-Carrion et al. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published Manuscript version of a Published Work that appeared in final form in PLoS ONE. To access the final edited and published work see https://doi.org/10.1371/journal.pone.0162476
Abstract
Intrinsically photosensitive retinal ganglion cells (ipRGCs), whose photopigment melanopsin has a peak of sensitivity in the short wavelength range of the spectrum, constitute a common light input pathway to the olivary pretectal nucleus (OPN), the pupillary light reflex
(PLR) regulatory centre, and to the suprachiasmatic nuclei (SCN), the major pacemaker of
the circadian system. Thus, evaluating PLR under short wavelength light (λmax 500 nm)
and creating an integrated PLR parameter, as a possible tool to indirectly assess the status
of the circadian system, becomes of interest. Nine monochromatic, photon-matched light
stimuli (300 s), in 10 nm increments from λmax 420 to 500 nm were administered to 15
healthy young participants (8 females), analyzing: i) the PLR; ii) wrist temperature (WT) and
motor activity rhythms (WA), iii) light exposure (L) pattern and iv) diurnal preference (HorneÖstberg), sleep quality (Pittsburgh) and daytime sleepiness (Epworth). Linear correlations
between the different PLR parameters and circadian status index obtained from WT, WA
and L recordings and scores from questionnaires were calculated. In summary, we found
markers of robust circadian rhythms, namely high stability, reduced fragmentation, high
amplitude, phase advance and low internal desynchronization, were correlated with a
reduced PLR to 460–490 nm wavelengths. Integrated circadian (CSI) and PLR (cp-PLR)
parameters are proposed, that also showed an inverse correlation. These results demonstrate, for the first time, the existence of a close relationship between the circadian system
robustness and the pupillary reflex response, two non-visual functions primarily under melanopsin-ipRGC input.
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Citation
PLoS ONE, 2016, Vol. 11, Issue 9 : e0162476
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/