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Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas

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dc.contributor.authorTrovato, M.es
dc.contributor.authorGrosso, Maddalenaes
dc.contributor.authorVitarelli, E.
dc.contributor.authorRuggeri, R.M.
dc.contributor.authorAlesci, S.
dc.contributor.authorTrimarchi, F.
dc.contributor.authorBarresi, G.
dc.contributor.authorBenvenga, S.
dc.date.accessioned2011-06-08T09:02:40Z
dc.date.available2011-06-08T09:02:40Z
dc.date.issued2003
dc.description.abstractHepatocyte growth factor (HGF), HGF receptor (c-met) and the interleukin 6 (IL-6) are expressed in thyroid nodules. In extra-thyroidal tissues, the HGF/c-met and IL-6/IL-6 receptor (IL-6R) systems activate STAT3, a member of the signal transducers and activators of transcription (STATs) family. To evaluate whether either system utilizes STAT3 in thyroid nodules, we examined the immunohistochemical expression of HGF, c-met, IL-6, IL-6R, STAT3 in 6 normal thyroids and in 68 thyroid nodules. STAT3 expression was observed in 12/12 (100%) papillary thyroid carcinomas (PTC) but in none of the follicular tumors. Among benign thyroid nodules, only 2/10 (20%) follicular adenomas (FA) were STAT3+. All these 14 STAT3+ cases expressed both HGF and c-met, but only 5 PTC co-expressed IL-6 and IL-6R and the 2 FA were IL-6+ but IL-6R-. The remaining 8 FA were all HGF-/c-met-, but IL-6+; of these 8, only 2 were also IL- 6R+. In conclusion, in thyroid nodules STAT3 is expressed only in PTC and a number of FA. Since these cases are consistently HGF+/c-met+ and only one-third of them co-express IL-6/IL-6R, STAT3 expression correlates with the HGF/c-met expression, not with the IL-6/IL-6R expression. The 100% rate of expression of the HGF/c-met/STAT3 signaling in PTC could be relevant for the establishment of the papillary phenotype. Because of the communeness of a HGF/c-met/STAT3 pattern between all PTC and a subset of FA, we speculate that a fraction of FA may progress to PTC.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21416
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHepatocyte growth factores
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleDistinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.18, nº 2 (2003)