Publication: The toxic effects of bis (tributyltin) oxide on the rat thoracic aorta
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Date
1992
Authors
Yoshizuka, M. ; Hara, K. ; Doi, K. ; Mori, Naoki ; Yokoyama, M. ; Ono, Eizo ; Fujimoto, Sunao
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The toxic effects of bis (tributyltin) oxide
(TBTO) on the ultrastructure and permeability of rat
thoracic aorta were studied electron microscopically and
the accumulation sites of tin were determined with an
X-ray microanalyzer.
Male Wistar rats received O.O5ml/kg of TBTO as an
emulsion in 1 m1 of distilled water througb a stomach
tube. After time intervals of 2, 4, 6, 8, 10, 12 h after
intubation, thoracic aortae were isolated and prepared
for electron microscopy.
Marked swelling of mitochondria in the aortic
endothelial cells appeared at 4 h after TBTO treatment.
By x-ray microanalysis, tin L-a peaks (3.44 keV) were
obtained from these swollen mitochondria.
Subendothelial edema progressed between 6 and 8 h
after TBTO treatment. By tracer experiment, it was seen
that large amounts of peroxidase reaction products filled
the expanded subendothelial space. At 12 h after TBTO
treatment, degenerative changes of the endothelial cells
were prominent. These results indicated that orally
administered TBTO accumulated in the mitochondria of
the endothelial cells of thoracic aorta. The direct toxic
effects of TBTO on mitochondria might induce severe
damage to the endothelial cells and cause disturbance of
the permeability barrier function of the endothelial layer
and subendothelial edema.
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