Effect of octreotide on expression of calcitonin gene in cultured cells of medullary thyroid carcinoma

Publication:
Effect of octreotide on expression of calcitonin gene in cultured cells of medullary thyroid carcinoma

dc.contributor.author	Zabel, M.	es
dc.date.accessioned	2011-06-08T09:08:41Z
dc.date.available	2011-06-08T09:08:41Z
dc.date.issued	2004
dc.description.abstract	The studies were performed on cultured TT cells, originating from medullary thyroid carcinoma and producing calcitonin (CT) and CT gene-related peptide (CGRP), synthesized on the template of the same gene. Addition of octreotide (a synthetic somatostatin analogue) to the cell culture augmented amounts of CGRP mRNA and of CGRP protein in the cells as well as increased levels of CGRP in the culture medium. In contrast, amounts of CT mRNA and of CT protein in the cells as well as levels of CT in the medium remained unchanged. The results showed that octreotide stimulates transcription and alternate splicing of the CT gene.	es
dc.format	application/pdf	es
dc.format.extent	5	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/21578
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Octreotide	es
dc.subject	Medullary thyroid carcinoma	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología	es
dc.title	Effect of octreotide on expression of calcitonin gene in cultured cells of medullary thyroid carcinoma	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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