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Sustainable Biocatalytic Procedure for Obtaining New Branched Acid Esters

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dc.contributor.authorMontiel, M.C.
dc.contributor.authorAsensi, M.
dc.contributor.authorGimeno-Martos, S.
dc.contributor.authorMáximo, F.
dc.contributor.authorBastida, J.
dc.contributor.departmentIngeniería Química
dc.date.accessioned2024-01-31T10:00:29Z
dc.date.available2024-01-31T10:00:29Z
dc.date.issued2021-11-13
dc.description©<2021>. This manuscript version is made available under the CC-BY license http://creativecommons.org/licenses/by/4.0/ This document is the Published version of a Published Work that appeared in final form in [Materials]. To access the final edited and published work see [https://doi.org/10.3390/ma14226847]
dc.description.abstractBiocatalytic synthesis of 2-ethylhexyl 2-methylhexanoate is described in this work for the first time. This branched-chain ester is suitable for use at low temperatures in numerous applications. The immobilized lipase Novozym® 435 has demonstrated its ability to catalyze the ester synthesis from 2-ethylhexanol and 2-methylhexanoic acid in a solvent-free medium. The high reaction times that are required result in a loss of alcohol by evaporation, which must be compensated for with an excess of this substrate if high conversions are to be achieved. Therefore, two strategies are established: 70 ◦C with a 10% excess of alcohol, which requires a longer operating time and provides conversions of 97%, and 80 ◦C with a 20% excess of alcohol, which allows for the achievement of a 99% conversion in a shorter time. The optimal reaction conditions have been chosen based on reusability of the enzyme, process productivity, green metrics and preliminary economic study. When the synthesis is carried out under the best conditions (70 ◦C, 10% molar excess of alcohol and six uses of the immobilized enzyme) a productivity of 203.84 kg product × kg biocatalyst−1 is attained. The biocatalytic procedure matches many of the objectives of “green chemistry” and is suitable to be scaled up and used in industrial manufacturinges
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationMaterials 2021, 14(22), 6847
dc.identifier.doihttps://doi.org/10.3390/ma14226847
dc.identifier.issnPrint: 0168-1656
dc.identifier.urihttp://hdl.handle.net/10201/138265
dc.languageenges
dc.publisherMDPI
dc.relationOrganismo financiador: Ministerio de Ciencia, Innovación y Universidades. Convocatoria: Proyectos de I+d+i Retos investigación 2018. Proyecto: PROCESOS SOSTENIBLES PARA LA SINTESIS BIOCATALITICA DE ESTERES RAMIFICADOS. Código: RTI2018-094908-B-I00es
dc.relation.publisherversionhttps://www.mdpi.com/1996-1944/14/22/6847es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBbiocatalysis
dc.subjectBranched-chain acid ester
dc.subjectSolvent-free
dc.subjectProcess productivity
dc.subjectGreen metrics
dc.subjectEconomic assessment
dc.subject.otherCDU::5 - Ciencias puras y naturales::54 - Química
dc.titleSustainable Biocatalytic Procedure for Obtaining New Branched Acid Esterses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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