Publication: Tight junctions and their role in cancer metastasis
Authors
Martin, T. A. ; Jiang, W. G.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Tight Junctions gove rn the permeabili ty of
endothelial and epithelial cells and are the most topical
structures of these cell types. Tight junctions create an
intercell ular ba rri er and in tramembrane diffusion fe nce.
An important step in the fo rmation of ca ncer metastases
is int e rac ti on and pe netrat io n o f th e vasc ula r
endothelium by dissociated ca ncer cells.
Ea rly studies demonstrated a correlation between the
reduction of tight junctions and tumour diffe rent iati on
and experimental evidence has emerged to pl ace tight
junctions in the frontline as the structure that ca ncer cells
must overcome in order to metastasise. Changes in tight
juncti on function are thu s an ea rl y and key aspect in
cancer metastasis.
Further work is requ ired to fully realise the potent ial
that this structure has in cancer invasion and metastasis
in ord er to deve lop new and nove l th erapi es in th e
prevention of tumour metastasis.
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Citation
Histology and histopathology, Vol. 16, nº 4 (2001)
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