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N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition

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dc.contributor.authorNguyen, Phuong Thao
dc.contributor.authorKudo, Yasusei
dc.contributor.authorYoshida, Maki
dc.contributor.authorKamata, Nobuyuki
dc.contributor.authorOgawa, Ikuko
dc.contributor.authorTakata, Takashi
dc.date.accessioned2016-02-08T16:52:23Z
dc.date.available2016-02-08T16:52:23Z
dc.date.issued2011
dc.description.abstractThe loss of E-cadherin and the gain of Ncadherin expression are known as “cadherin switching”. Cadherin switching is a major hallmark of epithelialmesenchymal transition (EMT). EMT is a crucial process in cancer progression, providing cancer cells with the ability to escape from the primary focus, to invade stromal tissues and to migrate to distant regions. Although down-regulation of E-cadherin is well known in various cancers, there are a few studies on N-cadherin expression in cancer. Here, therefore, we investigated whether N-cadherin expression was associated with the progression of head and neck squamous cell carcinoma (HNSCC). First, we examined the expression of Ncadherin by immunohistochemistry and its correlation with clinico-pathological findings. High expression of N-cadherin was observed in 52 of 80 HNSCC cases and was significantly correlated with malignant behaviors. Next, we examined the correlation between N-cadherin and E-cadherin. Cadherin switching (high expression of N-cadherin and low expression of E-cadherin) was found in 30 of 80 HNSCC cases and was well correlated with histological differentiation, pattern of invasion and lymph node metastasis in HNSCC cases. Moreover, we examined the expression of N-cadherin and E-cadherin by RT-PCR in 16 HNSCC cell lines to confirm the immunohistochemical findings. N-cadherin expression was observed in 7 of 16 HNSCC cells, and cadherin switching was observed in 2 HNSCC cells. Interestingly, HNSCC cells with cadherin switching have EMT features. In conclusion, we suggest that i) N-cadherin may play an important role in malignant behaviors of HNSCC, and ii) cadherin switching might be considered as a discrete critical event in EMT and metastatic potential of HNSCC.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/47797
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 26, nº 2 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectSquamous cell carcinomaes
dc.subject.other61 - Medicinaes
dc.titleN-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transitiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº2 (2011)