Publication: Morphological changes associated with long-term potentiation
Authors
Agnihotri, N. ; Lopez-Garcia, J.C. ; Hawkins, R.D. ; Arancio, O.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Long-term potentiation (LTP) is a longlasting
form of synaptic plasticity induced by brief
repetitive afferent stimulation that is thought to be
associated with learning and memory. It is most
commonly studied in the hippocampus where it may last
for several weeks, and involves the synthesis of new
proteins that might play a structural role. In this review
we summarize the evidence in favor of modifications of
neuronal architecture during LTP. We focus our attention
on changes occurring at the level of single synapses,
including components of postsynaptic dendrites
(dendritic spines, the postsynaptic density, and synaptic
curvature), of presynaptic terminals, and the formation
of new synapses. We conclude that although many
morphological changes at various sites have been
observed during LTP, there is no definitive proof in favor
of structural changes associated with LTP. However,
morphological modifications remain a valid candidate
for mechanisms of learning and memory.
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