Publication: Facts and paradoxes in current
notions of nuclear organization and function
Authors
Manfredi Romanini, M.G. ; Fraschini, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Invisible compartments, identified rather by
their activities than by their morphology, seem to operate
in the nucleus. These compartments interrelate
somehow, including mediation by the nuclear matrix. As
our knowledge about the nucleus increases, more
paradoxes become evident. We here consider some of
them: 1) the well-known C-paradox of Cavalier-Smith,
conceming the disproportionate amount of nuclear DNA
content in comparison with the amount of DNA
potentially able to transcribe; 2) the DNA folding in the
chromatin fibre and its superorganization within the
nucleus, which seems to be in opposition with the
transcribing and self-replicating activities; 3) the elusive
role of the DNA sequences with different degrees of
repetitivity; and 4) the compartmentalization in the
nucleus and how it relates to transcription, processing
and transport of transcripts, and to DNA reduplication.
We conclude by introducing the concept of species
specific, minimal, but essential genome components, ¡.e.
the elusive few thousand DNA bases that, in our
hypothesis, act as a functional bridge between the
nuclear matrix and chromatin.
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