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Gut microbiome modification through dietary intervention in patients with colorectal cancer: protocol for a prospective, interventional, controlled, randomized clinical trial in patients with scheduled surgical intervention for CRC

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dc.contributor.authorMartínez-Sánchez, María Antonia
dc.contributor.authorNúñez-Sánchez, María Ángeles
dc.contributor.authorBalaguer-Román, Andrés
dc.contributor.authorOliva-Bolarín, Alba
dc.contributor.authorPujante-Gilabert, Gabriel
dc.contributor.authorHernández-Agüera, Quiteria
dc.contributor.authorMesa-López, María José
dc.contributor.authorEgea Valenzuela, Juan
dc.contributor.authorQueipo-Ortuño, María Isabel
dc.contributor.authorRuiz Alcaraz, Antonio José
dc.contributor.authorFerrer Gómez, Mercedes
dc.contributor.authorGil-Martínez, José
dc.contributor.authorRamos-Molina, Bruno
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-14T06:54:21Z
dc.date.available2026-01-14T06:54:21Z
dc.date.copyright© 2022 by the authors
dc.date.issued2022-06-22
dc.description.abstractColorectal cancer (CRC) is the third most common cancer and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including heritable and environmental factors, which are the latest to be closely associated with nutritional habits, physical activity, obesity, and the gut microbiota. The latter may also play a key role in CRC prognosis and derived complications in patients undergoing surgery. This is a single-center, open, controlled, randomized clinical trial, in patients with scheduled surgical intervention for CRC. The primary objective is to assess whether a pre-surgical nutritional intervention, based on a high-fiber diet rich in polyunsaturated fatty acids (PUFAs), can reduce disturbances of the gut microbiota composition and, consequently, the rate of post-surgical complications in patients with CRC. Patients will be randomized in a 1:1 ratio after receiving a diagnosis of CRC. In the control arm, patients will receive standard nutritional recommendations, while patients in the intervention arm will be advised to follow a high-fiber diet rich in PUFAs before surgery. Participants will be followed up for one year to evaluate the overall rate of postsurgical complications, recurrences of CRC, response to adjuvant therapy, and overall/disease-free survival.
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dc.format.extent11
dc.identifier.citationJ. Clin. Med. 2022, 11, 3613
dc.identifier.doihttps://doi.org/10.3390/jcm11133613
dc.identifier.eissn2077-0383
dc.identifier.urihttp://hdl.handle.net/10201/186509
dc.languageeng
dc.publisherMDPI
dc.relationThis work was funded by the Institute of Health “Carlos III” (ISCIII), and co-funded by the Fondo Europeo de Desarrollo Regional-FEDER (grant number PI20/00505). B.R-M was supported by the “Miguel Servet Type I” program (CP19/00098, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER). M.A.M-S was supported by a PFIS contract from the ISCIII (FI21/00003, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER), MIQ-O is recipient of a “Miguel Servet Type II” program (CPI13/00003) from ISCIII, co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Madrid, Spain, and also belongs to the regional “Nicolas Monardes” research program of the Consejería de Salud (C-0030-2018, Junta de Andalucía, Spain.
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/11/13/3613
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGut microbiota
dc.subjectColorectal surgery
dc.subjectAnastomotic leak
dc.subjectNutritional therapy
dc.subjectColorectal cancer
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleGut microbiome modification through dietary intervention in patients with colorectal cancer: protocol for a prospective, interventional, controlled, randomized clinical trial in patients with scheduled surgical intervention for CRC
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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