Publication: Immunohistochemical expression and localization of MMP-9, MMP-13, E-Cadherin and Ki-67 in road pavers' skin chronically exposed to bitumen products.
Authors
Loreto, Carla ; Lombardo, Claudia ; Caltabiano, Rosario ; Filetti, Vera ; Vitale, Ermanno ; Seminara, Danilo ; Castorina, Sergio ; Fenga, Concettina ; Ledda, Caterina ; Rapisarda, Venerando
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-116
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info:eu-repo/semantics/article
Description
Abstract
To investigate the matrix metalloproteinase
(MMP)-9, (MMP)-13, E-Cadherin and Ki-67
expressions in road pavers’ skin chronically exposed to
bitumen products in order to contribute to a better
understanding of the earlier tissue alteration. Skin punch
biopsies from 16 daily exposed workers and a control
group were studied by immunohistochemistry.
Morphometric and densitometric analyses were also
conducted. Morphological specimen evaluation of skin
of road pavers showed epidermal thinning, flattening and
loss of intercellular junction with a decreased expression
of E-cadherin confined to the basal skin layer, together
with MMP-9 and MMP-13 overexpressions in all
epidermis layers, vascular structures and adnexa. No
immunohistochemical alteration was reported for Ki-67
vs normal skin. Results from this study show that
overexpression of MMP-9 and MMP-13 may represent
an early response of the first human barrier to exposure
to bitumen products. Regulation of MMPs could be one
of the strategies to prevent primary skin disease.
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Citation
Histology and Histopathology Vol. 34, nÂş 10 (2019)
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