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Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation

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dc.contributor.authorGalvez-Sánchez, Carmen María
dc.contributor.authorMuñoz Ladrón de Guevara, Cristina
dc.contributor.authorMontoro, Casandra
dc.contributor.authorFernández-Serrano, María José
dc.contributor.authorDuschek, Stefan
dc.contributor.authorReyes del Paso, Gustavo
dc.contributor.departmentPersonalidad, Evaluación y Tratamiento Psicológicos
dc.date.accessioned2024-02-05T11:50:59Z
dc.date.available2024-02-05T11:50:59Z
dc.date.issued2018-08-01
dc.description© 2018, the authors. This manuscript version is made available under the CC-BY license http://creativecommons.org/licenses/ccby/4.0/ This document is the published version of a published work that appeared in final form in PLoS One. To access the final edited and published work see https://doi.org/10.1371/journal.pone.0201488
dc.description.abstractBackground: Fibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain and diffuse tenderness, accompanied by complaints including morning stiffness, fatigue, insomnia and affective symptoms. In addition, affected patients frequently experience cognitive impairments such as concentration difficulties, forgetfulness or problems in planning and decision-making. These deficits are commonly ascribed to interference between nociceptive and cognitive processing. Method: The present study investigated the association of cognitive performance with (a) pain responses to low intensity pressure stimulation (0.45-2.25 kg/cm2), (b) responses to stronger (above-threshold) stimulation (2.70 kg/cm2), and (c) pain threshold and tolerance in 42 women with FMS. Tests of attention, memory, processing speed, and executive functions were applied. Results: While no significant correlations were seen for pain threshold and pain tolerance, inverse associations arose between pain intensity ratings during pressure stimulation and performance in all evaluated cognitive domains. The magnitude of the correlations increased with decreasing stimulus intensity. Conclusions: It may be concluded that pain experience during somatosensory stimulation of low intensity is more closely related to attention, memory and executive functions in FMS than the traditional measures of pain threshold and pain tolerance. Considering that pain responses to low intensity stimulation reflect the hyperalgesia and allodynia phenomena characterizing FMS, it may be hypothesized that central nervous pain sensitization is involved in cognitive impairments in the disorder.es
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dc.format.extent12es
dc.identifier.citationPLoS One, 13(8), e0201488, 2018
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0201488
dc.identifier.issnElectronic: 1932-6203
dc.identifier.urihttp://hdl.handle.net/10201/138633
dc.languageenges
dc.publisherPublic Library of Sciencees
dc.relationEsta investigación se ha desarrollado en el marco de un Proyecto del Ministerio de Ciencia e Innovación cofinanciado con fondos FEDER (Proyecto PSI2015-69235P) y un contrato predoctoral FPU (ref: FPU2014-02808) de una beca del Ministerio de Educación, Cultura y Deporte (MECD) otorgada a la autora principal del artículo.es
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201488
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectFibromyalgia syndromees
dc.subjectCognitive performance
dc.subjectPain threshold
dc.subjectPain tolerance
dc.subjectCentral nervous pain sensitization
dc.titleCognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Estudio financiado por el Proyecto Marcadores objetivos de diagnóstico en la fibromialgia: sumación temporal del dolor, flujo sanguíneo. Investigador responsable: Reyes-Del Paso, Gustavo Adolfo. Nº Investigadores: 11. Participación: Investigadora. Entidad financiadora: Programa financiador: Ministerio de Economía y Competitividad y Fondo Europeo de Desarrollo Regional (FEDER). Referencia: PSI2015-69235-P (MINECO/FEDER). Fecha Inicio-Fin: 01/01/2016-31/12/2018. Cuantía concedida: 28.677,00€.
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