Publication: Lymphovascular invasion: assessment and
prognostic impact in melanoma and breast cancer
Authors
Thompson, Nicola ; Storr, Sarah ; Zhang, Siwei ; Martin, Stewart
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-11-615
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info:eu-repo/semantics/article
Description
Abstract
The presence of lymphovascular invasion is
a recognised poor prognostic factor in a wide range of
tumour types. Vascular invasion was historically
identified through haematoxylin and eosin staining,
however this technique is non-specific and differentiates
poorly between blood and lymphatic vessels. Newer
techniques using immunohistochemistry allow more
sensitive and specific identification of lymphovascular
invasion and are able to accurately differentiate between
lymphatic and blood vessels.
This review will discuss the current methods
available for the assessment of lymphovascular invasion.
Additionally, it will focus on the role of lymphovascular
invasion in breast cancer and melanoma, discussing the
relative importance of lymphatic and blood vessel
invasion in each tumour type.
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Citation
Histology and histopathology, Vol. 30, nº 9 (2015)
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