Publication: Expression of transforming growth factor í3 isoforms
and their receptors during hair growth phases in mice
Authors
Wollina, Uwe ; Lange, D. ; Funa, K. ; Paus, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Transforming growth factor B (TGF-6) is a
family of potent growth inhibitor proteins, often
produced as a precursor and often secreted in a complex
with the latent TGF-B binding protein (LTBP). We
investigated the expression of TGF-B1, 42, 43, LTBP,
TGF-B receptor proteins type 1 and type 11 (TBR-1 and
-11) during induced hair growth in C57 BL-6 mice. We
here demonstrated that TGFBs and TBR-1 are expressed
in hair follicle epithelium and have found a positive
reactivity for LTBP and TBR-1 in sebocytes. Dermal
tissue was weakly stained for LTBP and TGF-B3. In
early anagen the inner hair root sheath epithelium
expressed TGF-B1, whereas outer hair root was positive
for TBR-1 during anagenlcatagen switch. TER-11 was
found in sebaceous glands without significant variations
during the hair cycle. We may conclude that in follicle
epithelium TGF-Bl is not produced in a complex
together with LTBP. On the other hand, it is possible that
other types of LTBP, like LTBP-2 and LTBP-3, are
present, which are not detected by the antibody we used.
Furthermore, a very rapid secretion of LTBP fromproducing
cells may prevent immunohistochemical
detection. TGF-Bl released by inner hair root sheath
may regulate outer root sheath growth. A bidirectional
interaction of sebocytes and hair follicle epithelium in
the TGF-BILTBP seems possible. Sebocytes can be
considered to be a target for TGFs since they express
both TBR-1 and -U. The general properties of TGF-B as a
growth inhibitor of epithelial cells may suggest a
possible involvement in either the abrogation of
extensive growth at the end of anagen or the initiation of
catagen for the follicle epithelium as well as growth
control for sebaceous glands.
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