Publication: Lectin , UEA- 1, reaction of capillary endothelium with reference to permeability in autopsied cases of cerebral infarction
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Date
1986
Authors
Eizi Kadota ; Kurenai Tanji ; Shozo Nishida ; Manabu Takahashi ; Mitsuyo Maeda ; Shingo Hiruma ; Yoshiki Enomoto ; Shigeo Hashimoto ; Fumiharu Akai
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The relationship between endothelial reactivity
to Ulex europaeus agglutinin-1 (UEA-I) and the
permeability of the vascular wall in human autopsied cases
ol' cerebral infarction was studied. Sections from the
cerebral cortex were reacted with horseradish peroxidase
UEA-1 to demonstrate the surface membrane of endothelial
cells. Albumin in the neuropil of sections was de~nonstrated
for the estimation of increased vascular permeability. The
results showed that endothelial reactivity to UEA-I was
reduced in cases where death had occurred 3 to 5 days after
onset of cerebral infarction. Reactivity was also diminished
in cases where death had occurred after 13 and 25 days;
these cases showed fresh ischemic lesions caused by reattacks
of infarction. Albumin extravasation into the
neuropil was demonstrated in these intermediate cases.
Chronic cases, dying after more than 52 days, showed no
reduction of endothelial reactivity to UEA-I and no
albumin extravasation was proved.
It was concluded that UEA-1 can be employed as a
useful n~orphological marker for evaluation of endothelial
function and vascular permeability.
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Citation
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