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Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin

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dc.contributor.authorLucas-Sánchez, Alejandro
dc.contributor.authorAlmaida Pagán, Pedro Francisco
dc.contributor.authorMartínez-Nicolás, Antonio
dc.contributor.authorMadrid, Juan Antonio
dc.contributor.authorMendiola, Pilar
dc.contributor.authorCosta, Jorge de
dc.contributor.departmentFisiología
dc.date.accessioned2024-06-19T10:59:21Z
dc.date.available2024-06-19T10:59:21Z
dc.date.copyright© 2013 Elsevier Inc.
dc.date.issued2013-03-04
dc.description.abstractAdult (48-week-old) and senescent (72-week-old) individually-kept Nothobranchius korthausae were used as experimental subjects to characterise circadian system (CS) function and age-related changes in enescent fish. This species was specifically chosen because it has already shown potential for use as a model system in gerontological studies. The rest-activity rhythm (RAR) in fish can be easily monitored and used to characterise the state of the CS, and it has also been proposed as a reliable model to study sleep-like periods in fish. As they aged, N. korthausae experienced a significant decrease in total daily activity and a progressive impairment of the RAR, accompanied by changes in the regularity, fragmentation and amplitude of the rhythm. The ability of the CS to oscillate autonomouslywhen the twomain synchronizers, photoperiod and feeding time,were absent (continuous darkness and randomfeeding), was also impaired with age, as the capacity to re-synchronise to the light–dark (LD) cycle declined. Melatonin treatment improved the regularity, fragmentation and amplitude of the RAR in senescent fish, and it also improved sleep efficiency. In conclusion,N. korthausae represents a viablemodel for studying the aging of the circadian system and the restorative effect of chronobiotic substances, such as melatonin.es
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dc.format.extent10es
dc.identifier.citationExperimental Gerontology 48 (2013) 507–516
dc.identifier.doihttps://doi.org10.1016/j.exger.2013.02.026
dc.identifier.issnPrint: 0531-5565
dc.identifier.urihttp://hdl.handle.net/10201/142442
dc.languageenges
dc.publisherElsevieres
dc.relationThis project was funded by the Seneca Foundation (12005/PI/09), the Instituto de Salud Carlos III (RETICEF, RD12/0043/0011) and the Spanish Ministry of Science and Education (BFU2010-21945-C02-01), including FEDER cofunding.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0531556513000661?via%3Dihubes
dc.rightsAttribution 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCircadian systemes
dc.subjectAging
dc.subjectRest-activity rhythms
dc.subjectSleep
dc.subjectMelatonin
dc.subjectNothobranchius
dc.titleRest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonines
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersión
dspace.entity.typePublicationes
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